Thymic involution and immune reconstitution
نویسندگان
چکیده
منابع مشابه
Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution.
Despite recent progress in our understanding of the biology of T-cell homeostasis, clinically available therapies to substantially improve immune reconstitution in patients sustaining T-cell depletion are lacking. T cells are regenerated via a dynamic interplay between thymopoiesis and thymic-independent homeostatic peripheral expansion (HPE). Using athymic mice subjected to T-cell depletion, w...
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The thymus constitutes the primary lymphoid organ responsible for the generation of naive T cells. Its stromal compartment is largely composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for thymocyte maturation and selection. With senescence, a steady decline in the thymic output of T cells has been observed. Numeric and qu...
متن کاملIMMUNOBIOLOGY Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution
Despite recent progress in our understanding of the biology of T-cell homeostasis, clinically available therapies to substantially improve immune reconstitution in patients sustaining T-cell depletion are lacking. T cells are regenerated via a dynamic interplay between thymopoiesis and thymicindependent homeostatic peripheral expansion (HPE). Using athymic mice subjected to T-cell depletion, we...
متن کاملGenetic regulation of thymic involution.
In this review, we have summarized our work using combined complex statistical genetics, bioinformatics, and functional genomics to determine the genetic basis of the age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice and the parental B6 and D2 mice. We have shown that these mice provided a valuable genetic model that can permit resampling of thymuses from different aged...
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Inflammatory Bowel Disease (IBD) is a chronic relapsing inflammatory disorder of the gastrointestinal tract, comprising ulcerative colitis and Crohn’s disease. Alterations in T cell subsets, an important cell type in cell-mediated immune responses in the adaptive immune system, are certainly an element contributing to disease development. The relationship between disease and T-cell maturation i...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2009
ISSN: 1471-4906
DOI: 10.1016/j.it.2009.04.003